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In the first study, hamsters were injected with a pseudovirus was created that expressed surface Spike protein, while in the second the researchers just injected the protein directly into mice. The pseudovirus team went on to compare endothelial cells with different mutational forms of the ACE2 surface protein SD, with increased stability and SL, with decreased stability. There are several reasons why the situation is different. The viral infection process leads at the end to lysis of the the host cell and subsequent dumping of a load of new viral particles — and these get dumped into the cellular neighborhood and into the bloodstream. They then have a clear shot at the endothelial cells lining the airway vasculature, which are the very focus of these two new papers.
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Spike Protein Behavior

Note: This alphabetical index to the Guide to Federal Records in the National Archives of the United States is based on a paper version with the same title compiled in The index does not reflect updates to the Guide. The updated web version of the Guide can be searched with the Search the Guide feature.
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